The incident happened at about 7:30pm.
The fire was said to have started at a Total Fuel station and extended to another station.
Two huge explosions happened minutes apart.
Some students at some hostels at the University of Ghana campus, close to where the incident happened took to their heels.
Many residents in the area at Haatso, Madina and the UPSA area have abandoned their homes running further down to safety.
WATCH HOW IT ALL HAPPENED: